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Outline

  1. Introduction
  2. Literature review
    1. Historical perspective and evol...
    2. Lipid metabolism and therapeu...
    3. Role of signaling pathways and...
  3. Conclusion

The Development of Atherosclerosis Research

  1. Introduction

Atherosclerosis research has evolved into a cornerstone of cardiovascular medicine, reflecting centuries of scientific inquiry aimed at understanding the mechanisms underlying one of the leading causes of morbidity and mortality worldwide. Initially identified in ancient populations, as evidenced by atherosclerotic lesions in Egyptian mummies (Shi & Hu, 2006), its study began with rudimentary observations of vascular rigidity and progressed through pivotal discoveries in lipid metabolism, vascular biology, and immunology. In the 19th and early 20th centuries, the lipid hypothesis established cholesterol as a major factor in atherogenesis, a perspective that shaped decades of research and therapeutic development (Zhou, Manli, et al.). However, as scientific tools and methodologies advanced, a more nuanced understanding emerged, reframing atherosclerosis as a multifaceted chronic inflammatory disease (Sun et al., 2018).

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Initially identified in ancient populations, as evidenced by atherosclerotic lesions in Egyptian mummies (Shi & Hu, 2006) , its study began with rudimentary observations of vascular rigidity and progressed through pivotal discoveries in lipid metabolism, vascular biology, and immunology. In the 19th and early 20th centuries, the lipid hypothesis established cholesterol as a major factor in atherogenesis, a perspective that shaped decades of research and therapeutic development (Zhou, Manli, et al.) . However, as scientific tools and methodologies advanced, a more nuanced understanding emerged, reframing atherosclerosis as a multifaceted chronic inflammatory disease (Sun et al., 2018) .

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Initially identified in ancient populations, as evidenced by atherosclerotic lesions in Egyptian mummies(Shi & Hu, 2006), its study began with rudimentary observations of vascular rigidity and progressed through pivotal discoveries in lipid metabolism, vascular biology, and immunology. In the 19th and early 20th centuries, the lipid hypothesis established cholesterol as a major factor in atherogenesis, a perspective that shaped decades of research and therapeutic development(Zhou, Manli, et al.) . However, as scientific tools and methodologies advanced, a more nuanced understanding emerged, reframing atherosclerosis as a multifaceted chronic inflammatory disease(Sun et al., 2018) .

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